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The worldwide Vitamin D Deficiency pandemic

Research has shown that the incidence of many diseases could be dramatically 

reduced by increasing serum vitamin D levels often abbreviated 25-OH.

Vitamin D has become a very hot topic in recent years: Increasing serum Vitamin D levels to 35 ng/mL could prevent 30% of myocardial infarctions in men and reduce the risk of fracture in elderly people by 50%. Increasing serum vitamin D level to approximately 40 ng/mL could reduce the risk of

cancer in postmenopausal women by 35%.  and reduce the risk of falls in elderly people

by 50%.  Increasing serum vitamin D levels to to 50 ng/mL could reduce the incidence of breast

cancer by as much as 80%, multiple sclerosis by as much as 60%, and type I

diabetes by up to 50%.

There is no clear answer to why Vitamin D is so beneficial; says the author? There is no clear answer at present. However, anything that has such wide-ranging benefits has to possess the ability to modulate inflammation. Indeed, studies have shown that vitamin D inhibits nuclear factor Kappa beta, a protein that plays a key role in the inflammatory response and in the proliferation of cancer cells. It has also been shown to lower levels of the inflammatory marker C-Reactive protein, often abbreviated CRP. Thus, it is vital that we ensure our patients are getting plenty of vitamin D supplementation.The reference range for vitamin D is 33-105 ng/mL. Given the evidence published in the medical literature

over the last few years, it is advisable to try and keep patients at the top end of the reference range. Therefore, we should be aiming for 75-100 ng/mL. The optimal dose is 5000 to 15000 international units per day. However, this should be lowered for people who get a lot of sun exposure. It is also advisable to regularly check serum calcium in patients who take supplementary vitamin D, just to ensure there is no risk of hypercalcemia.

Just FYI, there has not been any evidence of Vitamin D toxicity at doses less than 30000 units per day. 

As an Anti-aging, Metabolic and Functional Medicine expert, I would consider Vitamin D a vital part for any treatment with any suspicion of Vitamin D deficiency.  Vitamin D saliva testing kits are available at Pharmaprodia. To order, please call 623-404-1000 or visit our website at

Need more information, please contact Richard Nkwenti; R.Ph, ABAAHP; FAAMFM

Reference: Anti Aging Therapeutics Volume XIV; Pages 163 author Ron Rothenberg; MD