Low Dose Naltrexone; Its uses, recommended doses and important information

What is Low Dose Naltrexone (LDN). How can It help Physicians treat patients appropriately? What type of indications are appropriate for LDN. What are the adverse effects of Low dose Naltrexone.

LDN is considered a non-opiate prescription medication in the United States (not a controlled substance). It helps block opiate receptors at a regular dosage of 50mg (available at most if not all retail pharmacies. It helps in alcohol overdose and most narcotic overdoses.  However, lower dosages has been found useful to have powerful anti-inflammatory benefits and thus useful for a variety of clinical conditions. It is utilized by most integrative, Functional, Orthopedic and other Physicians worldwide off-label for appropriately treating pain and inflammatory conditions in multiple sclerosis, Crohn's disease, fibromyalgia, depression, cancer, weight loss, complex regional pain syndrome, lupus, Parkinson’s disease and Thyroid Disease.

LDN increases levels of endogenous opioid peptides, thereby helping promote healing  and inhibition of cell growth and reduction of inflammation. Also, through its ability to increase the level of endorphins, it also helps in the modulation of immune responses in the body and in the reduction of the speed at which undesirable cells grow and multiply in the body.

LDN has also been found to block the release of pro-inflammatory cytokines in humans including Interleukins IL-6 and IL-12, Tumor Necrosis Factor alpha (TNFα), NF-ĸB (nuclear factor kappa beta) and the modulation of the production of B and T lymphocytes. It has also been found that LDN helps a shift of the immune response from TH2 to TH1.  LDN antagonizes Toll like receptors (TLR) thereby helping in the suppression of cytokine modulated immune system.