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Estradiol, Estriol and Estrone

For many brain functions, the right amount of estrogen is important. Too much estrogen is harmful, but the quality of life of a woman who is deprived of estrogen also suffers. Often, she is complaining of foggy thinking, memory losses mainly linked to unknown names and sleep disorders, often along with the more common symptoms of vaginal dryness and hot flashes. Perceived female hormonal agents, estrogens also have important effects in the male biologic system. Positive findings were reported in bone, the brain and cardio physiology, while a possible role in the aging prostate pathology was seriously considered. Estrogens in men are primarily considered testicular and adrenal androgenic peripheral aromatization products. Though testicular and adrenal androgen development declines with age, degrees of total plasma estradiol do not decline. This is due to the typical increase in fat mass with aging (the peripheral aromatization substrate) and a boosted aromatase activity with aging. However, free, or bioavailable estrogens can decrease due to a rise in globulin binding sex hormone. Estrogens provide major skeletal growth and bone maturation benefits. Estrogens are better predictors of bone fractures than androgens. Estrogens have effects on the brain such as cognitive control, movement coordination, pain as well as affective state, and likely prevention from Alzheimer's disease. Estrogen effects on the cardiovascular system include lipid profiles, fat distribution, vascular-produced endocrine / paracrine elements (such as endothelin, nitric oxide), blood platelets, inflammatory variables, and coagulation. The possible negative effects of estrogens on the prostate may be due to a shift in estrogen / androgen ratio with aging. Estradiol (E2) is widely known as the female sex hormone. Since the discovery of estrogens in the early 1940s, it was generally assumed that such hormonal agents induced impairment of gonadal function in males or did not have any effect. New studies are contradictory to previous knowledge, shows an involvement of estrogens in the pathogenesis of certain systemic diseases found in men. Fat and the brain are the key source of E2 in humans. E2 is also produced in adrenal, liver, mammary, hair and male gonads. Blood levels of E2 in men are sometimes higher in men than in post postmenopausal women. E2 is crucial for spermatogenesis (O’Donnell, Robertson, Jones, & Simpson, 2001). The traditional view of E2's inhibitory role in male physiology was eventually shut down thanks to the discovery of estrogen receptors in males. The aromatase enzyme enables the conversion of testosterone into E2. Monitoring of men with inherited abnormalities of this genetics greatly expanded the understanding of the stimulatory function of E2 in men in improving bone stroma, inhibiting their direct growth, metabolic lipid rate as well as sexual maturation, the results that have been attributed to testosterone action until today. 

New research shows the role of estrogen in the emergency room in cardio-vascular system operation. aggravating the proliferative issues of these conditions. (Kula et al., 2005) Collagen serves as a buffer in the skin and adds water to the skin by increasing the volume of hyaluronic acid with the bio-identic estradiol restorations. This is because the dominant protein in cells with estrogen receptors attracts and binds estrogen to skin cells. Estrogen increases elastin in skin cells, resulting in increased blood flow, increased skin thickness and water, and decreased wrinkle size. In almost one hundred percent of these patients, the bio-identical estradiol cream used in postmenopausal women with usual symptoms of aging showed remarkable progress.