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Posted by Pharmaprodia on 05/14/2018

Compounding for HypoThyroidism

Compounding for HypoThyroidism

Compounding options for thyroid disorders

Your thyroid gland is a small gland in the front of your neck. It is located just below your larynx. It produces two thyroid hormones - triiodothyronine (T3) and thyroxine (T4) - which migrate through the blood to all tissues of the body. Thyroid hormones Is responsible for how our body breaks the food we eat down and converts thee food back into energy; it can either be for immediate use or as storage for the future use. In other words, our thyroid hormones regulate our body's metabolism.

What are the most common thyroid disorders?

Thyroid disorders are common in the general population and the prevalence increases with age. It is estimated that millions of people in the United States have some type of thyroid disease and that the majority of these people are women. Two of the most common thyroid disorders are:

  • Hyperthyroidism: If your thyroid gland is too active, it will produce more thyroid hormones than your body needs. This condition is called hyperthyroidism. Some common symptoms of hyperthyroidism include weight loss, increased heart rate and sensitivity to heat.
  • Hypothyroidism: Hypothyroidism is by far the most common thyroid disease in the adult population and is more common in older women. Hypothyroidism is that your thyroid is not working sufficiently active and produces less thyroid hormone than your body needs. It can make you gain weight, feel tired and have difficulties with low temperatures.

HOW IS HYPOTIRROIDISM TREATED?

Hypothyroidism can be treated with thyroid hormone replacement therapy. The goal of thyroid hormone treatment is to replicate the normal function of the thyroid gland. It is important to understand that each patient's therapy will be different. How the body absorbs hormones and the amount of hormones needed varies. Your treatment plan will be individualistic. Therefore, you should expect a certain amount of experimentation when it comes to finding the dose and form of therapy that is best for you.

It is estimated that more than half of all people who are affected by thyroid disease to their disease are not aware, although the patient may have many of the following symptoms of hypothyroidism:

  • Weight gain
  • Intolerance to cold and heat (cold hands and feet)
  • Fatigue
  • Reduced metabolism
  • Memory disorders and concentration
  • Fluid retention
  • Constipation
  • Dry skin and / or hair
  • Depression
  • Low sexual desire
  • Headache, migraine
  • Irregular menstrual cycles
  • PMS
  • Enlarged tongue
  • Swollen neck
  • Deep voice
  • Infertility
  • Hypoglycaemia (low blood sugar)

Patients may have some or most of the above symptoms, but they may not be diagnosed for years!

Types of thyroid medication

  • T4 thyroid medications

The most common thyroid treatment is a treatment with synthetic hormone T4. Sodium levothyroxine (T4), the most common form of treatment for hypothyroidism helps increase T3 levels through the introduction of additional amounts of T4 in the body so that more T3 in body tissues can be created than they need it. The rationale behind using levothyroxine sodium (T4) alone (monotherapy) is that the thyroid only makes 20% of the body’s T3—the other 80% is made from T4 elsewhere in the tissues of the body so by bringing up a patient’s T4, T3 ought be more readily made throughout the body. Levothyroxine is based on the conversion of T4 to T3 to combat the absence of both thyroid hormones throughout the body: only when T4 is successfully and efficiently converted to T3 does the body benefit from the favored sodium levothyroxine.

  • T3 Thyroid Medication

If you are a person who does not convert well T4 to T3, then you can prescribe T3 to supplement your drug T4. There are different types of T3 drugs, including synthetic preformed T3 (often prescribed as Cytomel) and compound T3 drugs that are cooked only for the exact strength and dose requirements of the patient, as specified by their doctor.

T3 does not remain active in your body for a long time. T3 pretreated medications, such as Cytomel, are only effective for approximately 10 hours and should be taken twice a day. Since they cause a sudden explosion and then decline active thyroid hormones , many patients feel nervous shortly after taking it and they will feel as if they had a drink of espresso and may feel weak or tired when the effectiveness wears off.

Compound T3 medications can be prepared in a prolonged-release formula to avoid patients with roller coaster hormone who often experience Cytomel and similar compounded medications. The downside of compound medicines is that some insurance companies do not cover them, and compound pharmacies are not as common as regular pharmacies, so finding one near you can be difficult. The good news is that compounded medicines made by compounded pharmacist are much less expensive than standard and regular medicines, so they are usually still affordable for most people to get, even without insurance most compounding pharmacies can send you their medicines.

Compounding options

Many patients have tried levothyroxine and liothyronine, and found that the natural thyroid is the only effective way that works for them. They just report that they do not feel so good and always feel uneasy when they take levothyroxine alone or with liothyronine. At present, certain forms and strengths of Natural Thyroid are only available through compounding pharmacies. In addition, compound pharmacies can prescribe T4 and T3 powders in a specific ratio.

Commercially available tablets contain fillers and excipients that can not be tolerated by all patients. When compounded pharmacies prepare custom-made doses, they have the ability to eliminate any inactive problematic ingredients and replace non-reactive fillers.

References 

Tan JL, Carpenter JM, Van achterberg C. Corrigenda: Tan J-L, Carpenter JM, van Achterberg C (2018) An illustrated key to the genera of Eumeninae from China, with a checklist of species (Hymenoptera, Vespidae). ZooKeys 740: 109-149. https://doi.org/10.3897/zookeys.740.22654. Zookeys. 2018;(753):163-167.

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