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Posted by Pharmaprodia on 02/19/2019

Are you on Hormone Replacement and want information on how to prevent Cancer, give us a call

Are you on Hormone Replacement and want information on how to prevent Cancer, give us a call

Estrogen is metabolized in the body through two major pathways and one minor pathway.

The two major pathways include the 2-hydroxyestrone pathway and the 16 Hydroxyestrone pathway.

The minor Pathway is the 4-hydroxyestrone pathway.

The preferred pathway is the 2-hydroxy pathway due to the fact that it does not stimulate the cells to divide. This division typically can lead to DNA Damage and tumor growth. Through its ability to attach to available estrogen receptors, 2-hydroxyestrone exhibits a blocking action that prevents an over-abundance of estrogen from over-controlling the cells. This has really been shown to have an anti-cancer effect.

On the other hand, the 16-hydroxyestrone metabolite is much more active with a very powerful (but undesirable) stimulatory effect on the receptors.  16 hydroxyestrone binds to receptors in the cells that can have the potential to increase the rate of cell multiplication and DNA synthesis. There is therefore strong research to show that the strong estrogenic activity of the 16-hydroxyestrone increases the risk of breast cancer significantly.

The 16-hydroxyestrone also permanently binds to the estrogen receptors while the 2-hydroxyestrone and others bind only temporarily to the receptors and then released.

Higher levels of 16-hydroxyestrone in cells has been associated with obesity, hypothyroidism, Omega-6-fatty acid excess and production of inflammatory cytokines.

Extensive endogenous and exogenous estrogen availability in the cells through the 16-hydroxy pathway puts the patient at higher risk for breast cancer.

Therefore, the lower the ratio of the 2-Hydroxyestrone to the 16 hydroxyestrone the higher the risk for breast cancer. On the other hand, the survival rate for breast cancer in women who already have breast cancer is higher in patients with high 2-hydroxyestrone ratio.

Consumption of cruciferous vegetables and brocolli , Diindolylmethane  which is most commonly called DIM, Indole-3-3-Carbinol, Calcium-D-Glucarate and others have been shown to enhance or favor the 2-hydroxyestrone metabolic pathway.

For more information, please call Pharmaprodia 623-404-1000

Richard Nkwenti; R.Ph; ABAAHP; FAAMFM; HRT Specialist; MSHS Integrative Medicine (Expected May 2019)

Reference: Integrative Medicine; 3rd Edition Pages 338 to 340 by David Rakel

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