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Current Anti-Aging Strategies and the scientific basis

Globally, age-related disorders are the main cause of death and morbidity. Because people are living longer, these diseases are becoming increasingly widespread. Some of the most common age-related disorders include Alzheimer's, cancer, stroke, and heart disease. These illnesses can have a significant influence on a person's quality of life and possibly result in death. Genetics, lifestyle decisions, and environmental exposures can all contribute to the development of certain disorders. Any disease's exact cause isn't always known. Age-related disorders are complex, and more study is needed to develop effective prevention and treatment measures.

Many chronic diseases, such as heart disease, stroke, and cancer, are linked to aging. According to estimates, the annual cost of healthcare for seniors in the United States would approach $1 trillion by 2050. We must identify effective strategies to slow aging and prevent the start of age-related chronic diseases as soon as possible. Numerous studies have shown that proper eating habits and regular exercise can help to slow down the aging process. There's also mounting evidence that vitamins like antioxidants and omega-3 fatty acids can help you age gracefully. More study is still needed in this area. There are numerous strategies to slow down aging and improve our chances of living a long and healthy life, according to the data.

Although some people find the concept of aging difficult to comprehend, there are a number of promising anti-aging methods now in research. Procedures such as augmentation of autophagy and senescent cell clearance, transfusion of young blood plasma, intermittent fasting enhancement of adult neurogenesis, physical activity, antioxidant intake, stem cell therapy, and transfusion of young blood plasma are among them. Clinical trials are still being conducted on several of these techniques. Other solutions, on the other hand, are now available and showing promising outcomes. Fasting on a regular basis has been demonstrated in studies to improve metabolic health and extend lifespan. Exercise has also been demonstrated to boost cognitive performance and lower the risk of age-related disorders. Although more research is needed to completely comprehend these anti-aging tactics, they provide hope to people who desire to delay the impacts of aging.

Numerous preclinical studies have demonstrated that there are numerous possibilities for preserving normal health as we age and delaying the onset of neurodegenerative disorders such as Alzheimer's disease. In animal models, the effectiveness of autophagy-enhancing medications, senolytic drugs, and plasma from young blood, as well as neurogenesis-inducing drugs and BDNF, has been proven.

With aging, autophagy, the mechanism by which cells recycle and break down their own components, decreases. To aid in the restoration of normal autophagic function, autophagy enhancers can be used. They help keep damaged cells from accumulating, which can contribute to age-related disorders. Senolytic medicines can kill senescent cells, or cells that have stopped developing, in a selective manner. These cells can build up over time, causing a variety of age-related problems, including neurodegeneration. Many elements in youthful blood plasma can help sustain proper brain function and avoid neurodegeneration. Neurogenesis-inducing drugs promote the formation of new neurons. This can be utilized to replace neurons that have died as a result of disease or aging. Finally, BDNF is a neuron-growth-promoting protein.

Calorie restriction (CR) is the practice of limiting food intake while still maintaining adequate nutrition. CR has been shown to increase lifespan and reduce the risk of age-related diseases in a variety of species, including rats, mice, and monkeys. However, the efficacy of CR in humans is less clear. Additionally, CR can be difficult to maintain long-term, making it impractical for many people.

Intermittent fasting (IF) is a form of CR that involves alternating periods of fasting and eating. IF has been shown to improve health and extend lifespan in animal studies, and there is some evidence that it may have similar benefits in humans. Unlike CR, IF does not require a constant reduction in food intake, making it easier to stick to long-term.

Physical activity has also been shown to improve health and extend lifespan in animal studies. Additionally, several observational studies have found that physically active people are less likely to die prematurely than sedentary people. Furthermore, exercise has been shown to improve mental health, quality of life, and cognitive function in older adults.

Antioxidants are substances that protect cells from damage caused by reactive oxygen species (ROS). ROS are produced as a byproduct of normal metabolism and

1.  Carnosine

Carnosine, also known as L-carnosine, is a chemical that occurs naturally in the body. It's best recognized for being a potent antioxidant. Carnosine is a dipeptide, or a molecule made up of two connected amino acids: beta-alanine and histidine, according to science. This molecule is specifically found in the active tissues of the body, such as the heart and brain. Carnosine has been demonstrated to help protect cells from free radical damage due to its antioxidant capabilities. Free radicals are unstable chemicals that can induce oxidative stress, a condition that has been related to a variety of chronic diseases. Carnosine has also been found to have anti-inflammatory and neuroprotective properties. Carnosine shows promise as a potential treatment for illnesses such as Alzheimer's disease and heart disease, while further research is needed.

Carnosine offers a number of health benefits for humans, including boosting brain, muscle, heart, and bone health. It also possesses high antioxidant and anti-inflammatory capabilities, which add to its total systemic protective potential. Carnosine supplementation has been found in clinical research to improve cognitive performance in healthy adults and may possibly be advantageous for people with neurodegenerative diseases like Alzheimer's and Parkinson's. Supplementing with carnosine has also been demonstrated to improve exercise performance and prevent muscle damage caused by exercise. Carnosine may be a beneficial natural supplement for boosting brain health, muscular function, and heart health, according to these studies.

2. Stem Cell Therapy

The prevalence of age-related degenerative disorders, such as Alzheimer's disease, is rising as people live longer. Effective medicines that improve the quality of life for patients and their families are urgently needed. Stem cell therapy is a viable treatment option for Alzheimer's disease and other brain degenerative diseases. Stem cells have been proven to promote the regeneration and function of the elderly or diseased brain in animal models. Human stem cell therapy is now undergoing clinical trials to determine its safety and efficacy. Stem cell therapy, if proven to be effective, could transform the treatment of degenerative brain illnesses and give hope to millions of patients and their families.


Shetty AK, Kodali M, Upadhya R, Madhu LN. Emerging Anti-Aging Strategies - Scientific Basis and Efficacy. Aging Dis. 2018 Dec 4;9(6):1165-1184. doi: 10.14336/AD.2018.1026. PMID: 30574426; PMCID: PMC6284760.

Artioli GG, Sale C, Jones RL. Carnosine in health and disease. Eur J Sport Sci. 2019 Feb;19(1):30-39. doi: 10.1080/17461391.2018.1444096. Epub 2018 Mar 4. PMID: 29502490.